Tuesday, June 3, 2008

Mitochondrial DNA I


Mitochondrial organelles, which contain mitochondrial DNA (mtDNA), are passed only from mother to offspring. A comparison of DNA sequences from mtDNA in a population reveals a molecular phylogeny. Unlike mtDNA, which is outside the nucleus, genes containing nuclear DNA become recombined after being inherited from both parents, and therefore we can be statistically less certain about nuclear DNA origins than we can for mtDNA, which is only inherited from the mother. mtDNA also mutates at a higher rate compared to nuclear DNA, so it gives researchers a more useful, magnified view of the diversity present in a population.Just as mitochondria are inherited matrilineally, Y-chromosomes are inherited patrilineally.Thus it is possible to apply the same principles outlined above to men. The common patrilineal ancestor of all humans alive today has been dubbed Y-chromosomal Adam. Importantly, the genetic evidence suggests that the most recent patriarch of all humanity is much more recent than the most recent matriarch, suggesting that 'Adam' and 'Eve' were not alive at the same time. While 'Eve' is believed to be alive 140,000 years ago, 'Adam' lived only 60,000 years ago